Challenges in Healthcare Innovation

watch time: 22 minutes

The U.S. spent $2.6 trillion on healthcare in 2010; this is expected to double by 2020. Why so expensive? And why has healthcare been so resistant to the innovations that could bring costs down; why is …

Bio Fund II

As history has shown, innovation in biology is really hard. Long timelines and expensive, unexpected failures are hallmarks of the biopharmaceutical and diagnostics industry. Software has been attempting to disrupt the industry for decades with limited success, for a variety …

Decrypting Crypto, From Bitcoin and Blockchain to ICOs

watch time: 21 minutes

On the surface, the story of cryptocurrencies has been a story about new financial opportunities — whether it’s people betting on bitcoin, or banking on the blockchain. But the building blocks of this story go back …

AI: What’s Working, What’s Not

watch time: 30 minutes

It’s the golden age of artificial intelligence (AI), a.k.a. machine learning, deep learning, and other distributed computing. But like every golden age, there’s a gold rush-like buzz in the air that makes it hard to tell …

10 Year Futures (Vs. What’s Happening Now)

The personal computer S-curve gave us 1.5 billion PCs and 3 billion people online, and now the smartphone S-curve is giving a computer to everyone on earth. So today, we have two innovation conversations: First, what can we build on …

a16z Podcast: A New Lab Rises

We’ve already talked quite a bit about the Algorithms, Machines, and People lab at U.C. Berkeley (AMPLab) — all about making sense of big data — so what happens when the entire world moves towards artificial intelligence — …

a16z Podcast: The Case Study of Lyft and Local Governments

How should startups engage with policymakers, build their own government relations (GR) function (whether in house or with consultants), and just begin to figure out their GR playbook? Let alone explain their moves — not just externally, but internally too?  …

a16z Podcast: Independents on the Board

“Orthogonal thinking” but “shared core values” — that’s what makes an ideal board… especially when it comes to “independents”, i.e., board members who aren’t also investors. But how do you get the most out of those independent directors, who are …

a16z Podcast: Making a (Really) Wild Geo-Engineering Idea Real

Here’s what we know: There’s a pair (father and son) of Russian scientists trying to resurrect (or rather, “rewild”) an Ice Age (aka Pleistocene era) biome (grassland) complete with (gene edited, lab-grown) woolly mammoths (derived from elephants). In Arctic Siberia …